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Nicotinamide Adenine Dinucleotide (NAD+) is a naturally occurring coenzyme found in your cells and plays a critical role in cellular metabolism and energy homeostasis. As we age, our NAD+ levels drop, but with new therapies available, we can help to restore it.
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The Science Behind NAD+ IV Therapy

NAD+ is the body’s natural solution. Discovered in 1906, this coenzyme powers the metabolic process that converts food into cellular energy. It exists in all living cells and impacts a wide range of systems, from digestion to cognition and aging. This makes it a powerhouse treatment via IV infusion therapy. NAD has been used to successfully increase energy and focus, improve cardiovascular health, minimize age-related diseases, and aid with addiction recovery and detox.

Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that serves as an essential cofactor and substrate for a number of critical cellular processes involved in oxidative phosphorylation and ATP production, DNA repair, epigenetically modulated gene expression, intracellular calcium signaling, and immunological functions.

NAD+ depletion may occur in response to either excessive DNA damage due to free radical or ultraviolet attack, resulting in significant poly(ADP-ribose) polymerase (PARP) activation and a high turnover and subsequent depletion of NAD+. Another cause of NAD+ depletion is chronic immune activation and inflammatory cytokine production resulting in accelerated CD38 activity and decline in NAD+ levels.

Recent studies have shown that enhancing NAD+ levels can profoundly reduce oxidative cell damage in catabolic tissue, including the brain. Therefore, promotion of intracellular NAD+ anabolism represents a promising therapeutic strategy for age-associated degenerative diseases in general, and is essential to the effective realization of multiple benefits of healthy sirtuin activity.

The kynurenine pathway represents the de novo NAD+ synthesis pathway in mammalian cells. NAD+ can also be produced by the NAD+ salvage pathway.

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